Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease.
نویسندگان
چکیده
Five Pt(II) complexes were tested for their ability to interfere in Cu(II) or Zn(II) coordination to the Aβ peptide. Two of them induce modifications of the Cu(II) sphere but not the associated Cu(Aβ) ROS production. In contrast, they do completely preclude Zn induced Aβ aggregation.
منابع مشابه
Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity.
Combined coordination of Zn(II) and Cu(I) or Cu(II) to the amyloid-β peptide has been investigated using XANES, EPR and NMR spectroscopies. While Zn(II) does alter Cu(II) binding to Aβ, this has no effect on (Aβ)Cu induced ROS production and associated cell toxicity.
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 21 شماره
صفحات -
تاریخ انتشار 2013